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Titre: | Keratoconus prognosis study for patients with corneal external mechanical stress mode |
Auteur(s): | Bettahar, Toufik Rahmoune, Chemseddine Benazzouz, Djamel |
Mots-clés: | Biomechanics Cornea Keratoconus Finite element analysis Cyclic loading Artificial neural network |
Issue Date: | 2020 |
Editeur: | Springer Nature |
Collection/Numéro: | Int Ophthalmol/ Vol. 40, N°7(2020);pp. 1673-1686 |
Résumé: | Purpose To demonstrate the correlation between
excessive eye rubbing and corneal degeneration for
Keratoconus patients.
Materials and methods Keratoconus (KC) patients
who regularly rub their eyes had shown a rapid
degeneration rate of their affected corneas. This
observation is experimentally and numerical discussed
and developed based on clinical data of 8 of KC
Patients with a mean age of 26.5 ± 9.4 years old, and
four healthy individuals with a mean age of
24.33 ± 5 years old at the baseline. Corneal topography
was used to measure both central corneal thickness
(CCT) and its total refractive power. The
registered data had been exploited to assess the
progression of the disease, and the final results were
embedded in a finite element model of human corneas
to simulate their response to eye rubbing at different
stages of the pathology. Corneal lifetime prognosis
using multi-layer perceptron was then established to
estimate the number of eye rubbing cycles for each
stage of KC.
Results The survey of KC patients who declared
stopping eye rubbing had shown a decrease in CCT
loss rate, followed by a durable stability. Mechanical
stresses numerical simulations had shown different
corneal behaviours in term of shape deformity, apical
raise and corneal applanation between healthy and KC
stages models. Apical rise ranged from 0.122 to
0.389 mm for an applied intraocular pressure that
equals to 15 mmHg. A normal stress of 5 kPa
provoked a corneal applanation that ranged from
0.27 mm in healthy cases to 1.173 mm in severe
stages of the disease. The application of 2.5 kPa
biaxial stress had resulted normal and tangential
applanations that successively ranged from 0.152
and 0.173 mm in healthy corneas to 0.446 mm and
0.458 mm in severe KC stages. An adopted prognosis
algorithm was able to predict the current stage of the
disease and to estimate the remaining number of eye
rubbing cycles before failure.
Conclusion Eye rubbing was proven to be a considerable
contributing factor in KC patient’s corneal
degeneration. The progression of this pathology could
be decreased or halted by stopping eye rubbing at early
stages. |
URI: | doi: 10.1007/s10792-020-01335-2 http://dlibrary.univ-boumerdes.dz:8080/handle/123456789/7073 |
Appears in Collections: | Publications Internationales
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